Das Karzinom in der Polarität zwischen Stoffwechsel- und Nerven-Sinnes-System – Konsequenzen für die Therapie

Henning Schramm
Article-ID: DMS-20795-DE
DOI: https://doi.org/10.14271/DMS-20795-DE

Zwei Aspekte sind von entscheidender Bedeutung für das lokale Krebsgeschehen. Erstens ist dies die aerobe Glyko lyse, die die ungehemmte Proliferation der Krebszellen ermöglicht, die notwendigen Bausteine dafür liefert und zugleich den oxidativen Stress in der Krebszelle erniedrigt. Hinzu kommen zweitens eine adrenerge Hyperinnervation und eine gesteigerte neuronale Aktivität des Tumors, wodurch er wie ein Wundgebiet, mit einer besseren Durchblutung versehen, vermehrt mit Nährstoffen versorgt, mit Immuntoleranz verbunden und zudem noch chronifiziert wird. Gesamtheitlich spielt sich das Tumorgeschehen im Organismus in einer dysfunktionellen Polarität zwischen dem Nerven-Sinnes-System und dem Stoffwechselsystem ab. Das dysfunktionelle Mittelhirn und angrenzende Gebiete wie der Hypothalamus sind entscheidend am Tumorgeschehen beteiligt. Anhand von naturwissenschaftlichen Erkenntnissen werde ich im folgenden Aufsatz diese Aspekte im Einzelnen darlegen und durch geisteswissenschaftliche Aussagen Rudolf Steiners in einen menschenkundlichen Zusammenhang stellen. Therapeutische Konsequenzen aus diesem Karzinomverständnis werden beschrieben und die Wirksamkeit der Misteltherapie entsprechend gedeutet.

Cancer between the opposite poles of metabolic and neurosensory system – consequences for treatment

Two aspects are of great significance for the local cancer process. The first is aerobic glycolysis which makes unhindered proliferation of cancer cells possible, providing the building stones for this and at the same time reducing oxidative stress in the cancer cell. The second aspect is adrenergic hyperinnervation and increase of neuronal activity of the tumour. This improves blood supply, as for a wound area, supplies more nutrients, is connected with immunotolerance and also makes the condition chronic. All in all tumours develop in the organism in a dysfunctional polarity between the neurosensory and the metabolic system. The dysfunctional mid-brain and adjacent structures such as the hypothalamus play a definite role in the tumour process. The above will be considered in detail on the basis of natural-scientific insights and placed in an anthroposophic context by referring to statements made by Rudolf Steiner. The consequences of this for the treatment of cancer will be described, with the efficacy of mistletoe therapy interpreted accordingly.

1 Hsu PP, Sabatini DM. Cancer cell metabolism: Warburg and beyond. Cell 2008;134(5):703–707. [Crossref]

2 Van der Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009;324 (5930):1029–1033. [Crossref]

3 Bhat PJ, Darunte L, Kareenhalli V, Dandekar J, Kumar A. Can metabolic plasticity be a cause for cancer? Warburg-Waddington legacy revisited. Clin Epigenetics 2011;2(2):113–122.

4 Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer 2004;4(11):891–899. [Crossref]

5 Stocks T, Rapp K, Bjorge T, et al. Blood glucose and risk of incident and fatal cancer in the metabolic syndrome and cancer project (me-can): analysis of six prospective cohorts. PLoS Med 2009;6(12):e1000201. [Crossref]

6 Kelly B, O’Neill LA. Metabolic reprogramming in macrophages and dendritic cells in innate immunity. Cell Res 2015;25(7):771–784. [Crossref]

7 Wang T, Marquardt C, Foker J. Aerobic glycolysis during lymphocyte proliferation. Nature 1976;261(5562):702–705. [Crossref]

8 Dienel GA, Cruz NF. Aerobic glycolysis during brain activation: Adrenergic regulation and influence of norepinephrine on astrocytic metabolism. J Neurochem 2016;138(1):14–52. [Crossref]

9 Pan L, Tang J, Liu H, Cheng B. Sympathetic nerves: How do they affect angiogenesis, particularly during wound healing of soft tissues? Clin Hemorheol Microcirc 2016;62(2):181–191. [Crossref]

10 Suchorolski MT, Paulson TG, Sanchez CA, Hockenbery D, Reid BJ. Warburg and Crabtree effects in premalignant Barrett’s esophagus cell lines with active mitochondria. PLoS One 2013;8(2):e56884. [Crossref]

11 Steiner R. Natur und Mensch in geisteswissenschaftlicher Betrachtung, Band VI. GA 352. Vortrag vom 23.01.1924. 3. Aufl. Dornach: Rudolf Steiner Verlag; 1981.

12 Steiner R. Rhythmen im Kosmos und im Menschen. Wie kommt man zum Schauern der geistigen Welt? Band IV. GA 350. Vortrag vom 22.09.1923. 3. Aufl. Dornach: Rudolf Steiner Verlag; 1991.

13 Steiner R. Geisteswissenschaft und Medizin. GA 312. Vortrag vom 27.03. 1920. 7. Aufl. Dornach: Rudolf Steiner Verlag; 1999. [Crossref]

14 Selg P. Mensch und Mistel. Band 1. Berlin: Salumed Verlag; 2016.

15 Steiner R. Erdenwissen und Himmelserkenntnis. GA 221. Vortrag vom 11.02. 1923. 4. Aufl. Dornach: Rudolf Steiner Verlag; 2015.

16 Hanel S. J. Michael Bishop and the discovery of the first human oncogene. Spektrum der Wissenschaft. Die Woche Spezial 2014: 8–10. Verfügbar unter www. spektrum-cp.com/wpcontent/uploads/2014/08/Woche_Sonderausgabe_Lindau.pdf (04.01.2017).

17 Anderson MW, Reynolds SH, You M, Maronpot RM. Role of proto-oncogene activation in carcinogenesis. Environ Health Perspect 1992;98:13–24. [Crossref]

18 Ryu TY, Park J, Scherer PE. Hyperglycemia as a risk factor for cancer progression. Diabetes Metab J 2014;38(5):330–336. [Crossref]

19 Plum L, Belgardt BF, Bruning JC. Central insulin action in energy and glucose homeostasis. J Clin Invest 2006;116(7):1761–1766. [Crossref]

20 Schwartz MW, Seeley RJ, Tschop MH, et al. Cooperation between brain and islet in glucose homeostasis and diabetes. Nature 2013;503(7474):59–66. [Crossref]

21 Qian J, Scheer FA. Circadian system and glucose metabolism: implications for physiology and disease. Trends Endocrinol Metab 2016;27(5):282–293. [Crossref]

22 Salageanu A, Tucureanu C, Lerescu L, et al. Serum levels of adipokines resistin and leptin in patients with colon cancer. J Med Life 2010;3(4):416–420.

23 Barb D, Williams CJ, Neuwirth AK, Mantzoros CS. Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence. Am J Clin Nutr 2007;86(3):s858–866.

24 Koch L, Wunderlich FT, Seibler J, et al. Central insulin action regulates peripheral glucose and fat metabolism in mice. J Clin Invest 2008;118(6):2132–2147. [Crossref]

25 Konner AC, Hess S, Tovar S, et al. Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis. Cell Metab 2011;13(6):720–728. [Crossref]

26 Blum K, Thanos PK, Gold MS. Dopamine and glucose, obesity, and reward deficiency syndrome. Front Psychol 2014;5:919. [Crossref]

27 Kleinridders A, Cai W, Cappellucci L, et al. Insulin resistance in brain alters dopamine turnover and causes behavioral disorders. Proc Natl Acad Sci USA 2015;112(11):3463–3468. [Crossref]

28 Thorens B. Brain glucose sensing and neural regulation of insulin and glucagon secretion. Diabetes Obes Metab 2011;13(Suppl 1):82–88. [Crossref]

29 Obici S, Feng Z, Karkanias G, Baskin DG, Rossetti L. Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat Neurosci 2002;5(6):566–572. [Crossref]

30 Abraham MA, Filippi BM, Kang GM, Kim MS, Lam TK. Insulin action in the hypothalamus and dorsal vagal complex. Exp Physiol 2014;99(9):1104–1109. [Crossref]

31 Steiner R. Geistige Zusammenhänge in der Gestaltung des menschlichen Organismus. GA 218. Vortrag vom 22.10.1922. 5. Aufl. Dornach: Rudolf Steiner Verlag; 2011.

32 Bensing S, Brandt L, Tabaroj F, et al. Increased death risk and altered cancer incidence pattern in patients with isolated or combined autoimmune primary adrenocortical insufficiency. Clin Endocrinol (Oxf) 2008;69(5):697–704. [Crossref]

33 Biswas M, Smith JC, Davies JS. Bilateral adrenal enlargement and non-suppressible hypercortisolism as a presenting feature of gastric cancer. Ann Clin Biochem 2004;41(Pt 6):494–497. [Crossref]

34 Zeitzer JM, Nouriani B, Rissling MB, et al. Aberrant nocturnal cortisol and disease progression in women with breast cancer. Breast Cancer Res Treat 2016;158(1):43–50. [Crossref]

35 Khan MW, Chakrabarti P. Gluconeogenesis combats cancer: opening new doors in cancer biology. Cell Death Dis 2015;(6):e1872. [Crossref]

36 Ma R, Zhang W, Tang K, et al. Switch of glycolysis to gluconeogenesis by dexamethasone for treatment of hepatocarcinoma. Nat Commun 2013;4:2508. [Crossref]

37 Dube S, Slama MQ, Basu A, Rizza RA, Basu R. Glucocorticoid excess increases hepatic 11beta-HSD-1 activity in humans: implications in steroidinduced diabetes. J Clin Endocrinol Metab 2015;100(11):4155–4162. [Crossref]

38 Coutinho AE, Kipari TM, Zhang Z, et al. 11beta-Hydroxysteroid Dehydrogenase type 1 is expressed in neutrophils and restrains an inflammatory response in male mice. Endocrinology 2016;157(7):en20161118. [Crossref]

39 De Feo P, Perriello G, Torlone E, et al. Contribution of cortisol to glucose counterregulation in humans. Am J Physiol 1989;257(1 Pt 1):E35–42.

40 Simmons PS, Miles JM, Gerich JE, Haymond MW. Increased proteolysis. An effect of increases in plasma cortisol within the physiologic range. J Clin Invest 1984;73(2):412–420. [Crossref]

41 Sephton SE, Sapolsky RM, Kraemer HC, Spiegel D. Diurnal cortisol rhythm as a predictor of breast cancer survival. J Natl Cancer Inst 2000;92(12):994–1000. [Crossref]

42 Heracek J, Urban M, Sachova J, et al. The endocrine profiles in men with localized and locally advanced prostate cancer treated with radical prostatectomy. Neuro Endocrinol Lett 2007;28(1):45–51.

43 James JH, Wagner KR, King JK, et al. Stimulation of both aerobic glycolysis and Na(+)-K(+)-ATPase activity in skeletal muscle by epinephrine or amylin. Am J Physiol 1999;277(1 Pt 1):E176–186.

44 Pocai A, Obici S, Schwartz GJ, Rossetti L. A brain-liver circuit regulates glucose homeostasis. Cell Metab 2005;1(1):53–61. [Crossref]

45 Tracey KJ. Physiology and immunology of the cholinergic antiinflammatory pathway. J Clin Invest 2007;117(2):289–296. [Crossref]

46 Zaenker KS, Entschladen F. Neuronal Activity in Tumor Tissue. Vol 39. Basel: Karger; 2007. [Crossref]

47 Krysiak R, Okopien B. Paraneoplastic endocrine syndromes. Przegl Lek 2016;73(1):29–39.

48 Honnorat J, Antoine JC. Paraneoplastic neurological syndromes. Orphanet J Rare Dis 2007;2:22. [Crossref]

49 De Couck M, Marechal R, Moorthamers S, Van Laethem JL, Gidron Y. Vagal nerve activity predicts overall survival in metastatic pancreatic cancer, mediated by inflammation. Cancer Epidemiol 2016;40:47–51. [Crossref]

50 De Couck M, van Brummelen D, Schallier D, De Greve J, Gidron Y. The relationship between vagal nerve activity and clinical outcomes in prostate and non-small cell lung cancer patients. Oncol Rep 2013;30(5):2435–2441. [Crossref]

51 Powe DG, Voss MJ, Zanker KS, et al. Beta-blocker drug therapy reduces secondary cancer formation in breast cancer and improves cancer specific survival. Oncotarget 2010;1(7):628–638. [Crossref]

52 Pongratz G, Straub RH. The sympathetic nervous response in inflammation. Arthritis Res Ther 2014;16(6):504. [Crossref]

53 Chiarugi P, Filippi L. Beta3-adrenoreceptor and tumor microenvironment: a new hub. Oncoimmunology 2015;4(11):e1026532. [Crossref]

54 Rybinski B, Franco-Barraza J, Cukierman E. The wound healing, chronic fibrosis and cancer progression triad. Physiol Genomics 2014;46(7):223–244. [Crossref]

55 Romana-Souza B, Monte-Alto-Costa A. Simultaneous blockade of alpha and beta adrenoreceptors impairs cutaneous wound healing in rats. J Eur Acad Dermatol Venereol 2010;24(3):349–352. [Crossref]

56 Romana-Souza B, Otranto M, Vieira AM, Filgueiras CC, Fierro IM, Monte-Alto-Costa A. Rotational stress-induced increase in epinephrine levels delays cutaneous wound healing in mice. Brain Behav Immun 2010;24(3):427–437. [Crossref]

57 Romana-Souza B, Porto LC, Monte-Alto-Costa A. Cutaneous wound healing of chronically stressed mice is improved through catecholamines blockade. Exp Dermatol 2010;19(9):821–829. [Crossref]

58 Schramm HM. Should EMT of cancer cells be understood as epithelial-myeloid Transition? J Cancer 2014;5(2):125–132. [Crossref]

59 Steiner R. Der Mensch als Zusammenklang des schaffenden, bildenden und gestaltenden Weltenwortes. GA 230. Vortrag vom 09.11.1923. 7. Aufl. Dornach: Rudolf Steiner Verlag; 1993.

60 Steiner R. Geisteswissenschaft und Medizin. GA 312. Vortrag am 03.04.1920. 7. Aufl. Dornach: Rudolf Steiner Verlag; 1999. [Crossref]

61 Steiner R. Physiologisch-Therapeutisches auf Grundlage der Geisteswissenschaft. GA 314. Vortrag vom 01.01. 1924. 4. Aufl. Dornach: Rudolf Steiner Verlag; 2010.

62 Keum N, Greenwood DC, Lee DH, et al. Adult weight gain and adiposity-related cancers: a dose-response meta-analysis of prospective observational studies. J Natl Cancer Inst 2015;107(2):djv088. DOI: https://doi.org/10.1093/jnci/djv088. [Crossref]

63 Latino-Martel P, Cottet V, Druesne-Pecollo N, et al. Alcoholic beverages, obesity, physical activity and other nutritional factors, and cancer risk: A review of the evidence. Crit Rev Oncol Hematol 2016;99:308–323. [Crossref]

64 Shephard RJ, Shek PN. Associations between physical activity and susceptibility to cancer: possible mechanisms. Sports Med 1998;26(5):293–315. [Crossref]

65 West AC, Bechtold DA. The cost of circadian desynchrony: Evidence, insights and open questions. Bioessays 2015;37(7):777–788. [Crossref]

66 Sung J, Song YM, Lawlor DA, Smith GD, Ebrahim S. Height and site-specific cancer risk: A cohort study of a Korean adult population. Am J Epidemiol 2009;170(1):53–64. [Crossref]

67 de Jonge PJ, Steyerberg EW, Kuipers EJ, et al. Risk factors for the development of esophageal adenocarcinoma in Barrett's esophagus. Am J Gastroenterol 2006;101(7):1421–1429. [Crossref]

68 Chatenoud L, La Vecchia C, Franceschi S, et al. Refinedcereal intake and risk of selected cancers in Italy. Am J Clin Nutr 1999;70(6):1107–1110.

69 Johnsen NF, Frederiksen K, Christensen J, et al. Wholegrain products and wholegrain types are associated with lower all-cause and cause-specific mortality in the Scandinavian HELGA cohort. Br J Nutr 2015;114(4):608–623. [Crossref]

70 Sieri S, Pala V, Brighenti F, et al. Dietary glycemic index, glycemic load, and the risk of breast cancer in an Italian prospective cohort study. Am J Clin Nutr 2007;86(4):1160–1166.

71 Joshi MN, Whitelaw BC, Palomar MT, Wu Y, Carroll PV. Immune checkpoint inhibitor related hypophysitis and endocrine dysfunction: Clinical Review. Clin Endocrinol (Oxf) 2016;85(3):331–339. [Crossref]

72 Koelzer VH, Rothschild SI, Zihler D, et al. Systemic inflammation in a melanoma patient treated with immune checkpoint inhibitors – an autopsy study. J Immunother Cancer 2016;4:13. [Crossref]

73 Radenkovic M, Ivetic V, Popovic M, Mimica-Dukic N, Veljkovic S. Neurophysiological effects of mistletoe (Viscum album L.) on isolated rat intestines. Phytother Res 2006;20(5):374–377. [Crossref]

74 Staudt A, Glenz A, Reinhard- Hennch B, Loewe-Mesh A, Lewicka S, Stammer H, Kuehn JJ, Abel U, Munzinger J, Schneeweis A, Sohn C, Strowitzki T. Diurnal cortisol profile in breast cancer patients before and during treatment with Viscum album (Iscador® P) for 3 or 6 months. Phytomedicine 2011;(18):25–26. [Crossref]

75 Gupta G, Kazmi I, Afzal M, et al. Sedative, antiepileptic and antipsychotic effects of Viscum album L. (Loranthaceae) in mice and rats. J Ethnopharmacol 2012;141(3):810–816. [Crossref]

76 Venturelli S, Burkard M, Biendl M, Lauer UM, Frank J, Busch C. Prenylated chalcones and flavonoids for the prevention and treatment of cancer. Nutrition 2016; 32(11–12):1171–1178. [Crossref]

77 Steiner R. Mensch und Welt. Das Wirken des Geistes in der Natur. Über das Wesen der Bienen, Band V. GA 351. Vortrag vom 31.10.1923. 5. Aufl. Dornach: Rudolf Steiner Verlag; 1999.

78 Steiner R. Geisteswissenschaft und Medizin. GA 312. Vortrag vom 02.04.1920. 7. Aufl. Dornach: Rudolf Steiner Verlag; 1999. [Crossref]

79 Knab AM, Lightfoot JT. Does the difference between physically active and couch potato lie in the dopamine system? Int J Biol Sci 2010;6(2):133–150. [Crossref]

80 Van Blarigan EL, Meyerhardt JA. Role of physical activity and diet after colorectal cancer diagnosis. J Clin Oncol 2015;33(16):1825–1834. [Crossref]

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J O B   M A R K E T

KINDERARZTPRAXIS, AARAU/SCHWEIZ
Praxisnachfolge: Kinder- oder Allgemeinarzt (m/w/d)
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FILDERKLINIK, FILDERSTADT
Oberarzt (m/w/d) Kardiologie, Intensivmedizin
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KREUZLINGEN, BODENSEE/SCHWEIZ
Hausarzt (m/w/d) oder Praxisgemeinschaft
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FILDERKLINIK, FILDERSTADT
Psychologe (m/w/d) 
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ALLGEMEINARZTPRAXIS,
ST. GALLEN/SCHWEIZ
Arzt (m/w/d) in Praxisgemeinschaft
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FILDERKLINIK, FILDERSTADT
Heileurythmist (m/w/d) in Teilzeit
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PARACELSUS-KRANKENHAUS UNTERLENGENHARDT, BAD LIEBENZELL
Assistenzarzt (m/w/d) für neue Schwerpunktstation
Integrative Schmerztherapie
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KLINIK ÖSCHELBRONN, ÖSCHELBRONN
Internisten (m/w/d)
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