Investigación en la medicina antroposófica

Última actualización: 01.06.2023

La investigación de la medicina antroposófica quiere fomentar el conocimiento de la base científica en la práctica clínica de todas las especialidades médicas. Es un ámbito de elevada actividad de investigación que evalúa la eficiencia, efectividad, seguridad y costos de las intervenciones. Analiza agentes activos y efectos fisiológicos, biioquímicos, celulares y genéticos de las distintas intervenciones. Investiga conceptos básicos, dimensiones antropológicas, el trasfondo histórico y las perspectivas de los pacientes y de las instituciones de salud o nuevas áreas innovativas. La investigación se realiza en instituciones alrededor de todo el mundo usando métodos establecidos, siguiendo lineamientos conductivos generales o desarrollando metodologías. Aquí presentamos, como ejemplo, resultados de estas investigaciones: https://medsektion-goetheanum.org/en/research/research-in-anthroposophic-medicine

 

 

Bibliografía

  1. Kienle GS, Albonico HU, Baars E, et al. Anthroposophic medicine: an integrative medical system originating in Europe. Global Advances in Integrative Medicine and Health 2013;2(6):20–31. DOI: https://doi.org/10.7453/gahmj.2012.087.
  2. Martin D. 100-year anniversary of anthroposophic medicine as an integrative medical system. Complementary Medicine Research 2020;27(6):375–378. DOI: https://doi.org/10.1159/000511668.
  3. Baars EW, Hamre HJ. Whole medical systems versus the system of conventional biomedicine: a critical, narrative review of similarities, differences, and factors that promote the integration process. Evidence-Based Complementary and Alternative Medicine 2017;2017:4904930. DOI: https://doi.org/10.1155/2017/4904930.
  4. Kienle GS, Ben-Arye E, Berger B, et al. Contributing to global health: development of a consensus-based whole systems research strategy for anthroposophic medicine. Evidence-Based Complementary and Alternative Medicine 2019;2019:3706143. DOI: https://doi.org/10.1155/2019/3706143.
  5. Baars EW, Kiene H, Kienle GS, et al. An assessment of the scientific status of anthroposophic medicine, applying criteria from the philosophy of science. Complementary Therapies in Medicine 2018;40:145–150. DOI: https://doi.org/10.1016/j.ctim.2018.04.010.
  6. Strasser F. Kriterien der Nutzenbewertung der Integrativen Medizin am Beispiel der Anthroposophischen Medizin. Der Merkurstab 2023;76(3):177-186. DOI: https://doi.org/10.14271/DMS-21636-DE.
  7. Koster EB, Baars EW, Delnoij DMJ. Patient-reported quality of care in anthroposophic and integrative medicine: A scoping review. Patient Education and Counseling 2020;103(2):276–285. DOI: https://doi.org/10.1016/j.pec.2019.09.010.
  8. Verfügbar unter https://www.escamp.org/ESCAMP_core_publications.html (10.8.2023).
  9. Baars EW, Kienle GS, Heusser P, et al. Anthroposophic medicinal products: a literature review of features, similarities and differences to conventional medicinal products, scientific and regulatory assessment. Global Advances in Integrative Medicine and Health 2022;11:21649561211073079. DOI: https://doi.org/10.1177/21649561211073079.
  10. Lötzke D, Heusser P, Büssing A. A systematic literature review on the effectiveness of eurythmy therapy. J Integr Med 2015;13(4):217–230. DOI: https://doi.org/10.1016/S2095-4964(15)60163-7.
  11. Dieses Kapitel ist eine auszugsweise Übersetzung des Beitrages: Kienle GS. Methodology and Case Reporting. Verfügbar unter https://medsektion-goetheanum.org/forschung/system-assessment-reviews-research-methods/methodology-and-case-reporting (10.8.2023).
  12. Hamre HJ, Glockmann A, Kienle GS, Kiene H. Combined bias suppression in single-arm therapy studies. Journal of Evaluation in Clinical Practice 2008; 14(5), pp. 923-929. DOI: https://doi.org/10.1111/j.1365-2753.2007.00903.x.
  13. Hamre HJ, Glockmann A, Tröger W, Kienle GS, Kiene H. Assessing the order of magnitude of outcomes in single-arm cohorts through systematic comparison with corresponding cohorts : an example from the AMOS study. BMC Medical Research Methodology 2008; 8, pp. 11. DOI: https://doi.org/10.1186/1471-2288-8-11.
  14. Kiene H. Komplementäre Methodenlehre der klinischen Forschung. Cognition-based Medicine. Berlin, Heidelberg, New York: Springer-Verlag 2001. Verfügbar unter http://www.ifaemm.de/Abstract/PDFs/CBM_Buch.pdf (12.09.203).
  15. Kiene H. Was ist Cognition-based Medicine? Zeitschrift für ärztliche Fortbildung und Qualitätssicherung im Gesundheitswesen 2005; 99:301-306. Verfügbar unter http://www.ifaemm.de/Abstract/PDFs/HK05_2.pdf (12.09.2023).
  16. Aronson JK. Adverse drug reactions and the role of case reports. 2009. Presented at "Celebrating case reports and stories in health care" at the Royal College of Physicians, London, UK. 15.5.2009.
  17. Kienle GS. Why Medical Case Reports? Global Advances in Integrative Medicine and Health 2012; 1(1):8-9. DOI: https://doi.org/10.7453/gahmj.2012.1.1.002.
  18. Kienle GS, Kiene H. Clinical Judgement and the Medical Profession. Journal of Evaluation in Clinical Practice. 2011;17(4):621-627. DOI: https://doi.org/10.1111/j.1365-2753.2010.01560.x.
  19. Gagnier JJ, Riley D, Altman D, et al. The CARE Guidelines : Consensus-based Clinical Case Report Guideline Development. Deutsches Ärzteblatt 2013;110(37):603-608. DOI: https://doi.org/10.3238/arztebl.2013.0603.
  20. Gagnier JJ, Kienle G, Altman DG, et al. The CARE guidelines : consensus-based clinical case report guideline development. Journal of Clinical Epidemiology 2014;67(1):46-51. DOI: https://doi.org/10.1016/j.jclinepi.2013.08.003.
  21. Abbing AC, Ponstein AS, Kienle GS, Gruber H, Baars E. The CARE-AAT Guideline : Development and Testing of a Consensus-based Guideline for Case Reports in Anthroposophic Art Therapy. The International Journal of Art Therapy 2016;21(2):46-55. DOI: https://doi.org/10.1080/17454832.2016.1170054.
  22. Kienle GS, Hamre HJ, Portalupi E, Kiene H. Improving the quality of therapeutic reports of single cases and case series in oncology : criteria and checklist. Alternative Therapies in Health and Medicine 2004;10:68-72. Verfügbar unter https://www.researchgate.net/publication/8236961_Improving_the_quality_of_therapeutic_reports_of_single_cases_and_case_series_in_oncology_-_Criteria_and_checklist (13.09.2023)
  23. Kienle GS, Kiene H. Kriterien für die Erstellung therapeutischer Einzelfallberichte in der Onkologie. Der Merkurstab 2003;56(1):2-5. DOI: https://doi.org/10.14271/DMS-18237-DE.
  24. Kienle GS, Kiene H. Zur Qualitätssicherung von Einzelfallberichten und Fallserien in der Onkologie. Deutsche Zeitschrift für Onkologie 2006;38(2):62-65. DOI: https://doi.org/10.1055/s-2006-932347.
  25. Kienle GS, Meusers M, Quecke B, Hilgard D. Patient-centered Diabetes Care in Children : An Integrated, Individualized, Systems-oriented, and Multidisciplinary Approach. Global Advances in Integrative Medicine and Health 2013;2(2):12-19. DOI: https://doi.org/10.7453/gahmj.2013.005.
  26. Werthmann PG, Helling D, Heusser P, Kienle GS. Tumour response following high-dose intratumoural application of Viscum album on a patient with adenoid cystic carcinoma. BMJ Case Reports 2014:bcr2013203180. DOI: https://doi.org/10.1136/bcr-2013-203180.
  27. Werthmann PG, Sträter G, Friesland H, Kienle GS. Durable Response of Cutaneous Squamous Cell Carcinoma Following High-dose Peri-lesional Injections of Viscum album Extracts : A Case Report. Phytomedicine 2013;20(3-4):324-327. DOI: https://doi.org/10.1016/j.phymed.2012.11.001.
  28. Reynel M, Villegas Y, Werthmann PG, Kiene H, Kienle GS. Long-Term Survival of a Patient with Recurrent Dedifferentiated High-Grade Liposarcoma of the Retroperitoneum Under Adjuvant Treatment with Viscum album L. Extract: A Case Report. Integrative Cancer Therapies 2021;20:1534735421995258. DOI: https://doi.org/10.1177/1534735421995258.
  29. Orange M, Poidimani N, Crosignani A, Werthmann PG, Bertotto C. Complete, Durable Remission of Advanced Hepatocellular Carcinoma under Treatment with Viscum album Extracts: A Case Report. Complementary Medicine Research 2022;29(6):483-491. DOI: https://doi.org/10.1159/000525409.
  30. Meyer R, Werthmann PG, Kienle GS. Reduction of the frequency of recurrent diverticulitis episodes under treatment with the integrative medicine therapies Carpellum Mali comp. and Kalium aceticum comp.-A case report. Complementary Therapies in Medicine 2018;40:203-206. DOI: https://doi.org/10.1016/j.ctim.2018.03.013.
  31. Werthmann PG, Inter P, Welsch T, Sturm AK, Grützmann R, Debus M, Sterner MG, Kienle GS. Long-term tumor-free survival in a metastatic pancreatic carcinoma patient with FOLFIRINOX/Mitomycin, high-dose, fever inducing Viscum album extracts and subsequent R0 resection: A case report. Medicine (Baltimore) 2018;97(49):e13243. DOI: https://doi.org/10.1097/MD.0000000000013243.
  32. von Schoen-Angerer T, Helmschmidt E, Madeleyn R, et al. A General Pediatrics and Integrative Medicine Approach to Pervasive Refusal Syndrome : A Case Report. Permanente Journal 2016;20(4):112-115. DOI: https://doi.org/10.7812/TPP/15-238.
  33. von Schoen-Angerer T, Madeleyn R, Kiene H, Kienle GS, Vagedes J. Improvement of Asthma and Gastroesophageal Reflux Disease With Oral Pulvis stomachicus cum Belladonna, a Combination of Matricaria recutita, Atropa belladonna, Bismuth, and Antimonite : A Pediatric Case Report. Global Advances in Integrative Medicine and Health 2016;5(1):107-111. DOI: https://doi.org/10.7453/gahmj.2015.019.
  34. von Schoen-Angerer T, Madeleyn R, Kienle G, Kiene H, Vagedes J. Viscum Album in the Treatment of a Girl With Refractory Childhood Absence Epilepsy. Journal of Child Neurology 2015;30(8):1048-1052. DOI: https://doi.org/10.1177/0883073814541473.
  35. von Schoen-Angerer T, Wilkens J, Kienle GS, Kiene H, Vagedes J. High-Dose Viscum album Extract Treatment in the Prevention of Recurrent Bladder Cancer : A Retrospective Case Series. Permanente Journal 2015;19(4):76-83. DOI: https://doi.org/10.7812/TPP/15-018.
  36. Deckers B, von Schoen-Angerer T, Voggenreiter B, Vagedes J. External Nursing Applications in the Supportive Management of Prolonged Postoperative Ileus : Description of Interventions and Case Report. Holistic Nursing Practice 2016;30(4):216-221. DOI: https://doi.org/10.1097/HNP.0000000000000158.
  37. Kienle GS, Glockmann A, Grugel R, et al. Klinische Forschung zur Anthroposophischen Medizin – Update eines „Health Technology Assessment“-Berichts und Status Quo. [Clinical research on anthroposophic medicine: update of a health technology assessment report and status quo.] Forschende Komplementärmedizin 2011;18(5):269–282. DOI: https://doi.org/10.1159/000331812.
  38. Hamre HJ, Kiene H, Ziegler R, et al. Overview of the publications from the Anthroposophic Medicine Outcomes Study (AMOS): A whole system evaluation study. Global Advances in Integrative Medicine and Health 2014;3(1):54–70. DOI: https://doi.org/10.7453/gahmj.2013.010.
  39. Harald J. Hamre, Helmut Kiene, Anja Glockmann, Renatus Ziegler, Gunver S. Kienle. Langzeitergebnisse für anthroposophische Behandlung chronischer Erkrankungen Eine 4-Jahres-Follow-up-Untersuchung mit 1.510 Patienten aus einer prospektiven Beobachtungsstudie in der ambulanten Routineversorgung. Der Merkurstab 2015;68(4):275-287. DOI: https://doi.org/10.14271/DMS-20514-DE.
  40. Verfügbar unter: https://www.leitlinienprogramm-onkologie.de/leitlinien/komplementaermedizin (22.02.2023).
  41. Baars E, Zoen EBV, Breitkreuz T, Martin D, Matthes H, von Schoen-Angerer T et al. The contribution of complementary and alternative medicine to reduce antibiotic use: a narrative review of health concepts, prevention, and treatment strategies. Evidence-Based Complementary and Alternative Medicine 2019;Article ID 5365608. DOI: https://doi.org/10.1155/2019/5365608.
  42. Martin DD. Fever: Views in Anthroposophic Medicine and Their Scientific Validity. Evidence-Based Complementary and Alternative Medicine 2016:3642659.DOI: https://doi.org/10.1155/2016/3642659.

Research news

Non-pharmacological interventions with good clinical evidence for chemotherapy-induced neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is the most common side effect for oncology patients. Therefore, their interest in complementary non-pharmacological therapies is high. A current scoping review presents the clinical evidence of therapies used in this context. Relevent studies published between 2000 and 2021 were analyzed. The panel of authors identified 17 supportive interventions, which they included in their assessment. Most were phytotherapeutic interventions including external applications and cryotherapy, hydrotherapy, and tactile stimulation. More than two-thirds of the consented interventions were rated with moderate to high perceived clinical effectiveness in therapeutic use. Therefore, the experts endorse these complementary procedures for the supportive treatment of CIPN. The review is available at: 
https://doi.org/10.3390/medsci11010015.